Best Shopify Agencies for Amazon Sellers Going DTC (2026)

The best Shopify agencies for Amazon sellers going DTC in 2026 are the ones that understand both sides of the move: marketplace economics and custom Shopify engineering. Most Shopify agencies have never sold a unit on Amazon, which is exactly where Amazon-to-DTC projects quietly go wrong. This guide ranks the agencies worth shortlisting, explains the criteria that actually matter for a marketplace seller, and shows where each one fits.

The short answer: best Shopify agencies for Amazon sellers going DTC

• Byteout — best for established Amazon sellers in health, beauty, supplements, and pet wellness who need the marketplace-to-DTC bridge handled by one team.
• Netalico — best for mid-market Shopify Plus builds, migrations, and ongoing development.
• Barrel — best for brand- and design-led DTC, with strong beauty and skincare work.
• Trellis — best for full-service Shopify Plus plus conversion optimization.
• Craftberry — best for supplement and beauty brands wanting a niche-focused build.
• Getmore — best for Shopify Plus in supplements, beauty, and food & beverage.
• eSEOspace — best for DTC brands prioritizing AI visibility (GEO/AEO) alongside the build.
• Velocity Sellers / SupplyKick — best when you want an Amazon-side agency that also touches DTC.

The rest of this guide explains how to choose between them, because the right answer depends on whether you lead with brand, engineering, niche, or marketplace fluency.

What makes a Shopify agency right for an Amazon seller?

An Amazon seller needs different things from a Shopify agency than a DTC-native brand does. Five criteria matter most:

1. Marketplace fluency. Do they understand ACoS, BSR, branded search, and how DTC pricing affects your Buy Box? An agency that has never sold on Amazon can build a store that quietly cannibalizes your best listings.
2. Channel strategy, not just a build. The hard part is deciding what to sell on DTC versus Amazon and how the two feed each other. That is a strategy question before it is a development question.
3. Retention and subscription experience. For consumable categories, the second purchase is where DTC pays back. The agency should know subscribe-and-save, replenishment, and lifecycle email, not just the storefront.
4. Real custom engineering. When off-the-shelf apps cannot do what your business needs (ERP, 3PL, Amazon sync, bespoke functionality), can they build it? Most theme shops cannot.
5. A focused niche. An agency that works in your category (supplements, beauty, pet) already knows the compliance, merchandising, and buyer psychology that move conversion.

How is building DTC for an Amazon seller different from a normal Shopify build?

The difference is that you already have revenue, customers, and listings you cannot afford to damage. A DTC-native brand starts from zero. An Amazon seller starts with a marketplace business that is still paying the bills, so the build has to protect it.

Done wrong, a DTC launch erodes your best ASINs through price conflicts and split demand. Done right, the DTC channel lifts Amazon performance: branded search grows, listing conversion improves, and repeat-purchase windows widen. In our own client work we have seen DTC campaigns produce a measurable Amazon revenue lift within the first 30 to 60 days, often as large as the DTC revenue itself. That spillover only happens when the agency understands both channels.

The best Shopify agencies for Amazon sellers going DTC (2026)

1. Byteout — the Amazon-to-DTC specialist

Byteout focuses specifically on established Amazon sellers in health, beauty, supplements, and pet wellness who are building a DTC pillar they own. The differentiator is that the team understands marketplace economics and custom Shopify engineering, so the Shopify store is built to lift Amazon performance rather than compete with it. 15 years in ecommerce, 200+ projects, Shopify certified, and named a top ecommerce developer in Miami by Clutch in 2024. Best for: 7-figure Amazon brands that want strategy, build, custom systems, and growth from one team. Watch for: a deliberately narrow niche, if you are outside consumer health/beauty/supplement/pet, another agency may fit better.

2. Netalico

A certified Shopify Plus partner known for mid-market DTC builds, replatforming, and long-term retainer support. Strong pick if your priority is solid Plus engineering and migration with one team for the years after launch. Less specialized in the Amazon marketplace side specifically.

3. Barrel

A brand- and design-led agency with notable beauty and skincare work. Best when brand identity, UX, and customer-research-driven design lead the project. A good fit for image-driven categories where the storefront experience is the differentiator.

4. Trellis

A full-service Shopify Plus agency that pairs development with conversion rate optimization. Worth shortlisting if you want build plus ongoing CRO under one roof and you have the traffic to test against.

5. Craftberry

A niche Shopify agency focused on supplement and beauty stores, with an emphasis on trust-building and frictionless purchase flows. A strong option if you want a partner that already works almost exclusively in your category.

6. Getmore

A Shopify Plus agency working with DTC and B2B brands in supplements, beauty, and food & beverage, with a focus on UX, CRO, and checkout extensibility for brands past $1M in revenue. Good for conversion-led Plus projects in consumable categories.

7. eSEOspace

Positions itself around AI visibility, merging Shopify development with GEO and AEO strategy so stores get discovered on Google, ChatGPT, Perplexity, and Gemini. Worth a look if being citable by AI search is a primary goal alongside the build.

8. Velocity Sellers and SupplyKick

These are Amazon-side agencies that have extended into omnichannel and DTC. Useful if you want a partner whose center of gravity is Amazon management and who treats Shopify as one more channel, rather than a Shopify-first engineering shop.

Quick comparison

Best Shopify agency by category

• Best for Amazon sellers specifically: Byteout, because the whole model is built around protecting and lifting the marketplace channel.
• Best for supplement brands: Craftberry or Getmore for niche focus; Byteout if subscription economics and Amazon overlap are central.
• Best for beauty and skincare: Barrel for brand-led design; Craftberry for category focus.
• Best for Shopify Plus migrations: Netalico or Trellis.
• Best for AI search visibility: eSEOspace.
• Best Amazon-first omnichannel: Byteout if in the beauty or supplements niche, otherwise Velocity Sellers or SupplyKick.

How should an Amazon seller choose?

Start with the constraint that matters most. If your biggest risk is damaging your Amazon business, prioritize marketplace fluency. If your biggest gap is brand, prioritize design. If it is purely engineering scale, prioritize a Plus specialist. Shortlist two or three, and on the first call ask each one how they would price your DTC catalog relative to Amazon. The answer tells you immediately whether they understand your business or just Shopify.

If you are an established Amazon seller in health, beauty, supplements, or pet wellness, see how we approach the move on our Shopify for Amazon sellers page, or look at real builds in our work.

Frequently asked questions

What is the best Shopify agency for Amazon sellers?

For established Amazon sellers in consumable categories, the best fit is an agency that understands both marketplace economics and custom Shopify engineering, so the DTC store lifts Amazon performance instead of competing with it. Byteout specializes in exactly this for health, beauty, supplements, and pet wellness brands. Netalico, Barrel, and Trellis are strong general Shopify Plus options.

Should an Amazon seller use a Shopify agency or an Amazon agency?

It depends on where your gap is. An Amazon agency like Velocity Sellers or SupplyKick is built around marketplace management. A Shopify agency is built around owning the DTC channel. For a seller whose goal is to build a brand and customer base they own, a Shopify agency with marketplace understanding is usually the better fit.

Will launching a Shopify store hurt my Amazon sales?

Not if it is built correctly. Poorly planned DTC launches create price conflicts that erode your Buy Box and split demand. A well-planned launch protects your listings and often lifts Amazon performance through stronger branded search. The agency you choose should be able to explain how they avoid cannibalization before they write any code.

How long does it take to launch a DTC Shopify store?

A focused, full-service launch typically runs 4 to 12 weeks depending on catalog complexity, integrations, and how much custom work is involved. Migrations and bespoke systems extend that timeline.

Building the Shopify side of an Amazon business is the core of what we do. If that is your situation, start here.